Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review of the Current Knowledge of Companion Animals.

H Gencoglu, et al. Multidisciplinary Digital Publishing Institute, (2020) Link to Study

This is a review of 18 studies involving arthritic humans, cats, rats, horses and dogs. Seven of these studies involved only dogs. 

Conclusions: 

• UC-II substantially contributes to lessening of pain and enhances freedom of movement in moderately arthritic dogs.
• Its beneficial effects are seen when used alone, and in combination with Glucosamine and Chondroitin.
• UC-II’s pain reduction effect is comparable to NSAIDS, but unlike NSAIDS, UC-II is well tolerated over time.